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目的观察灯盏花素佐治慢性阻塞性肺疾病急性加重期(AECOPD)的临床效果。方法将200例AECOPD患者随机分为观察组和对照组各100例。对照组给予常规治疗,观察组在对照组基础上加用灯盏花素治疗。均以14d为一疗程。对比2组咳嗽缓解时间、咯痰缓解时间、哮鸣音缓解时间和住院时间;对比2组治疗前后生活质量改善情况。结果观察组咳嗽缓解时间,咯痰缓解时间,哮鸣音缓解时间和住院时间均短于对照组(P<0.05)。对照组治疗后第1周生活质量评分虽低于治疗前,但差异无统计学意义(P>0.05),第2周生活质量评分低于治疗前(P<0.05)。观察组治疗后第1、2周生活质量评分均低于治疗前(P<0.05或P<0.01),且低于对照组(P<0.05)。结论灯盏花素佐治AECOPD,提高了患者的生活质量,且无明显不良反应,值得临床推广应用。
Objective To observe the clinical effect of breviscapine in treating acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods 200 patients with AECOPD were randomly divided into observation group and control group of 100 cases. Control group given conventional treatment, the observation group in the control group plus Breviscapine treatment. All 14d for a course of treatment. Cough relief time, expectoration relief time, wheeze relief time and hospital stay were compared between the two groups. The improvement of quality of life before and after treatment was compared between the two groups. Results The observation group cough relief time, expectoration relief time, wheeze relief time and hospital stay were shorter than the control group (P <0.05). The quality of life in the first week after treatment in the control group was lower than that before treatment, but the difference was not statistically significant (P> 0.05). The quality of life in the second week was lower than before treatment (P <0.05). The quality of life in the observation group after 1 and 2 weeks of treatment were lower than before treatment (P <0.05 or P <0.01), and lower than the control group (P <0.05). Conclusion Breviscapin adjuvant AECOPD improved the quality of life of patients with no obvious adverse reactions and is worthy of clinical application.