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目的分析蛋白激酶CK2α在卵巢癌中表达意义及其与基质金属蛋白酶-2(MMP-2)的相关性。方法采用免疫组织化学SP法检测卵巢单纯性囊肿,卵巢良性瘤,卵巢癌组织中CK2α和MMP-2的表达情况,同时选取正常卵巢组织作为对照。结果 CK2α在卵巢癌组织中的表达明显高于单纯性囊肿和卵巢良性组织(P<0.01);CK2α蛋白表达水平与组织分级和临床分期有关(P<0.05);CK2α与MMP-2在卵巢癌中的表达有一定的相关性(r=0.543)。结论 CK2α在卵巢癌中的表达明显升高,其与MMP-2在卵巢癌中有一定的相关性可能与肿瘤的发生发展、浸润、转移有密切关系。
Objective To analyze the expression of protein kinase CK2α in ovarian cancer and its relationship with matrix metalloproteinase-2 (MMP-2). Methods Immunohistochemical SP method was used to detect the expression of CK2α and MMP-2 in ovarian simple cyst, benign ovarian tumor and ovarian cancer, and normal ovarian tissue was selected as the control. Results The expression of CK2α in ovarian cancer was significantly higher than that in simple cysts and benign ovarian tissues (P <0.01). The protein expression of CK2α was correlated with the histological grade and clinical stage (P <0.05) There was some correlation between expression (r = 0.543). Conclusions CK2α expression in ovarian cancer was significantly increased, and its correlation with MMP-2 in ovarian cancer may be related to the occurrence and development of tumor, invasion, metastasis are closely related.