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目的 通过对布鲁氏菌属内Ｓ型与Ｒ 型菌种在小鼠和犬体内相互作用的研究，弄清我国布病防治中某些流行病学现象的机理。方法 将特定浓度的Ｓ型菌悬液分别与Ｒ 型菌液混合后注射于小白鼠和犬体内，２０ ～２５ 天后解剖取小鼠局部淋巴结、肝、脾及犬脾进行培养、分离及鉴定。结果 在小鼠试验中，各种Ｓ型布氏菌均明显地干扰了Ｒ 型犬种菌的生存。但在犬体内进行的研究表明，１０４Ｍ 菌被ＲＭ６／６６ 菌干扰；Ｒｅｖ － １ 菌与ＲＭ６／６６ 菌则或相互干扰，或相互平衡。Ｓ２ 在与ＲＭ６／６６ 相同菌量情况下，两者可以共存，以Ｓ２ 稍占优势，呈互不干扰、相互共处之态。结论 研究结果能合理解释Ｓ型布病疫区内很难分离到Ｒ 型布氏菌的流行病学现象，并阐明其流行病学意义。同时提示人们，当某地布病流行的优势菌被控制后，很可能出现新的优势种的布氏菌传播、流行
OBJECTIVE: To study the mechanism of some epidemiological phenomena in the control of brucellosis in Brucella by studying the interaction between S and R strains in mice and dogs. Methods S-type bacterial suspension with specific concentration was mixed with R-type bacterial liquid and then injected into mice and dogs respectively. Twenty-five to twenty-five days later, local lymph nodes, liver, spleen and spleen of mice were dissected for culture, isolation and identification. Results In mouse experiments, various S. brucellosus species clearly interfered with the survival of R type canine bacteria. However, studies conducted in dogs showed that 104M was disrupted by RM6 / 66; Rev - 1 and RM6 / 66 were either interfering with each other or in equilibrium with each other. S2 and RM6 / 66 in the same amount of bacteria, the two can co-exist, with a slight advantage of S2, were non-interfering with each other and coexistence of the state. Conclusions The results of the study can reasonably explain the epidemiology of Brucella R type isolates that are difficult to isolate in the S-type cloth epidemic area and elucidate its epidemiological significance. At the same time, people are reminded that when the predominant bacteria prevailing in a certain area are controlled, it is very likely that the new predominant species will spread and prevail