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目的探讨血液灌流(HP)联合血液透析(HD)治疗重度急性有机磷农药中毒的临床疗效。方法随机分为观察组(29例)和对照组(24例)。对照组入院后立即给予彻底洗胃、导泻、补液、利尿、尽快达阿托品化等处理及对症治疗,观察组在对照组治疗的基础上进行HP联合HD治疗。分别记录两组的阿托品用量以及治疗后患者清醒时间、胆碱酯酶(CHE)活力恢复时间、平均住院天数和病死率。结果观察组阿托品用量、恢复清醒时间、胆碱酯酶活性恢复时间、平均住院时间及病死率分别与对照组比较,差异均有统计学意义(P<0.05)。结论 HP联合HD治疗重度急性有机磷农药中毒疗效显著。
Objective To investigate the clinical effects of hemoperfusion (HP) and hemodialysis (HD) on severe acute organophosphorus pesticide poisoning. Methods Randomly divided into observation group (29 cases) and control group (24 cases). Control group immediately after admission to give gastric lavage, cathartic, rehydration, diuretic, as soon as possible treatment and symptomatic diatomine treatment, the observation group in the control group based on the treatment of HP combined with HD treatment. The amount of atropine and wakefulness of patients after treatment, recovery time of cholinesterase (CHE) activity, average days of hospitalization and mortality were recorded respectively. Results The amount of atropine in the observation group, recovery of awake time, recovery time of cholinesterase activity, average length of hospital stay and mortality were compared with the control group (P <0.05). Conclusion HP combined with HD treatment of severe acute organophosphorus pesticide poisoning significant effect.