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目的:研究胃癌组织中自发性细胞凋亡的发生情况及其临床意义。方法:采用TUNEL技术对53例胃癌组织中的凋亡细胞进行原位观察和比较。结果:胃癌组织自发性细胞凋亡指数平均为576%。胃癌细胞凋亡指数与患者年龄、性别、肿瘤大小、浸润深度无明显关系,与胃癌细胞分化程度、淋巴结转移及临床分期有关,高、中分化腺癌凋亡指数显著高于低分化腺癌(P<001),无淋巴结转移和临床Ⅰ、Ⅱ期胃癌凋亡指数显著高于有淋巴结转移和临床Ⅲ、Ⅳ期胃癌(P<005)。结论:提示胃癌组织自发性细胞凋亡与胃癌的某些生物学特性有密切的关系,细胞凋亡异常在胃癌发生发展过程中可能起重要作用。
Objective: To study the occurrence and clinical significance of spontaneous apoptosis in gastric cancer. Methods: TUNEL technique was used to observe and compare apoptotic cells in 53 cases of gastric cancer in situ. Results: The average apoptotic index of gastric cancer was 576%. The apoptotic index of gastric cancer cells was not significantly related to age, gender, tumor size and depth of invasion. It was related to differentiation of gastric cancer, lymph node metastasis, and clinical stage. The apoptotic index of high and moderately differentiated adenocarcinomas was significantly higher than that of poorly differentiated adenocarcinomas. P <001), apoptotic index of lymph node metastasis and stage I and II gastric cancer were significantly higher than those with lymph node metastasis and clinical stage III and IV gastric cancer (P <0.05). Conclusion: It is suggested that the spontaneous apoptosis of gastric cancer is closely related to some biological characteristics of gastric cancer. Abnormal apoptosis may play an important role in the development of gastric cancer.