目前已有不少与肿瘤发生发展相关的基因被发现与报道 ,并逐渐为人们所了解。新近发现位于3p2 1.3的RASSF1A基因在多种肿瘤中失活 ,包括小细胞肺癌、乳腺癌、胃癌及肾细胞癌等。研究表明RASSF1A作为一种候选肿瘤抑制基因参与肿瘤的发生发展 ,该基因的失活与其启动子区甲基化有关 ,另外亦发现某些病毒的感染可影响其甲基化状态。本文就RASSF1A基因与消化系肿瘤间的关系作一综述。 At present, many genes related to tumorigenesis have been found and reported, and gradually become known to the public. Recently, the RASSF1A gene located at 3p2 1.3 has been found to be inactive in many tumors, including small cell lung cancer, breast cancer, gastric cancer and renal cell carcinoma. Studies have shown that RASSF1A as a candidate tumor suppressor gene involved in tumor development, the gene inactivation and promoter methylation, also found that some of the virus infection can affect its methylation status. This article reviews the relationship between RASSF1A gene and gastrointestinal tumors.