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目的观察肺炎球菌疫苗与流感疫苗联合接种对反复呼吸道感染(RRTI)患儿体液免疫及疗效的影响。方法80例RRTI患儿随机分为4组:对照组(仅使用安慰剂)肺炎球菌疫苗组、流感疫苗组,联合疫苗接种组(接种肺炎球菌疫苗1月后再行流感疫苗接种),每组20例。末次接种后治疗12周后,测定患儿体液免疫功能指标,6月后观察临床疗效。同时选取2013年2月-2014年5月在本院治疗的非RRTI的急性呼吸道感染患儿30例。结果治疗12周后,RRTI组血清IgG、IgA和IgM水平明显低于非RRTI组(P<0.01)。治疗12周后,与对照组比较,肺炎球菌疫苗组、流感疫苗组和联合接种组患儿血清IgG、IgA和IgM水平、治疗总有效率明显上升(P<0.01),并且联合接种组明显优于单纯肺炎球菌疫苗组、流感疫苗组(P<0.05)。肺炎球菌疫苗组与流感疫苗组比较,差异无统计学意义(P>0.05),治疗期间无药物不良反应事件。结论肺炎球菌疫苗与流感疫苗联合接种可更有效地改善RRTI患儿的体液免疫功能。
Objective To observe the effect of combination of pneumococcal vaccine and influenza vaccine on humoral immunity and therapeutic effect in children with recurrent respiratory tract infection (RRTI). Methods Eighty patients with RRTI were randomly divided into 4 groups: control group (placebo only), pneumococcal vaccine group, influenza vaccine group and combination vaccine group (vaccinated with pneumococcal vaccine after January and influenza vaccine), and each group 20 cases. After the last vaccination for 12 weeks, the indicators of humoral immune function were measured in children and the clinical effects were observed after 6 months. Meanwhile, 30 patients with non-RRTI acute respiratory infection were treated in our hospital from February 2013 to May 2014. Results Serum IgG, IgA and IgM levels in RRTI group were significantly lower than those in non-RRTI group after 12 weeks of treatment (P <0.01). After 12 weeks of treatment, the serum total IgG, IgA and IgM levels in the pneumococcal vaccine group, the influenza vaccine group and the combined vaccination group were significantly higher than those in the control group (P <0.01), and the combined vaccination group was significantly superior In simple pneumococcal vaccine group, influenza vaccine group (P <0.05). Pneumococcal vaccine group and influenza vaccine group, the difference was not statistically significant (P> 0.05), no adverse drug reactions during treatment. Conclusion Combined pneumococcal vaccine and influenza vaccine can effectively improve the humoral immune function in children with RRTI.