强力枇杷冲剂药效毒性研究和临床观察

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强力批杷冲剂能抑制氨水所致小鼠咳嗽反射,提高家猫的引咳阈值,促进小鼠酚红排泌;明显抑制巴豆油所致小鼠耳肿胀,减轻角叉菜胶所致大鼠的踝关节肿胀,并在不同浓度下对金葡菌等细菌有抑制作用,显示本品有较强的镇咳、祛痰、抗炎、抗菌作用。本品ig一次最大耐受量为24g/kg,取两种剂量(1.8g和10.8g/kg,相当于临床量10倍和60倍)进行了4周给药试验,结果表明无明显毒性作用。临床用于咳嗽、支气管炎、慢性支气管炎等均获良好疗效。 Powerful granules can inhibit the cough reflex induced by ammonia in mice, increase the cough threshold of domestic cats, and promote the excretion of phenol red in mice; significantly inhibit the swelling of mice ears caused by croton oil, and reduce carrageenan-induced rats Swelling of the ankle joints and inhibition of Staphylococcus aureus and other bacteria at different concentrations show that this product has strong antitussive, expectorant, anti-inflammatory and antibacterial effects. The maximum tolerated dose of this product was 24g/kg. Two doses (1.8g and 10.8g/kg, equivalent to 10 times the clinical dose and 60 times the clinical dose) were administered for 4 weeks. The results showed no obvious Toxic effect. Clinically used for cough, bronchitis, chronic bronchitis and other good results.
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