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目的探讨瑞芬太尼联合丙泊酚在食管癌手术麻醉中的应用效果。方法选取2013年1月至2016年7月间四川省凉山州第一人民医院收治的50例食管癌手术患者,采用随机数表法分为观察组(采用瑞芬太尼联合丙泊酚麻醉)和对照组(采用芬太尼联合丙泊酚麻醉),每组25例。比较两组患者拔管后5min、10min的镇静效果及苏醒时间,以及两组患者的心率(HR)、收缩压(SBP)、舒张压(DBP)变化情况和麻醉期间的不良反应。结果观察组患者与对照组患者相比,拔管后5min、10min的镇静评分均明显增高,苏醒时间明显缩短,差异均有统计学意义(均P<0.05);观察组患者术后HR、SBP和DBP与对照组相比均明显降低,差异均有统计学意义(均P<0.05);观察组患者麻醉期间不良反应发生率与对照组相比显著降低,差异有统计学意义(P<0.05)。结论瑞芬太尼联合丙泊酚麻醉能够维持食管癌手术患者围术期血流动力学指标的稳定性,减少不良反应的发生,发挥较好的镇静、麻醉效果。
Objective To investigate the effect of remifentanil combined with propofol in surgical anesthesia of esophageal cancer. Methods Fifty patients undergoing esophageal cancer surgery from January 2013 to July 2016 in Liangshan Prefecture First People’s Hospital of Sichuan Province were randomly divided into observation group (remifentanil combined with propofol anesthesia) And control group (with fentanyl and propofol anesthesia), 25 cases in each group. The sedation and wakefulness at 5 and 10 minutes after extubation were compared between the two groups. HR, SBP, DBP and adverse reactions during anesthesia were compared between the two groups. Results Compared with patients in the control group, the sedation scores at 5 and 10 min after extubation were significantly increased, and the recovery time was significantly shorter (all P <0.05). The postoperative HR, SBP (P <0.05). The incidence of adverse reactions in the observation group was significantly lower than that in the control group (P <0.05), and the difference was statistically significant ). Conclusion Remifentanil combined with propofol anesthesia can maintain perioperative hemodynamic stability of esophageal cancer patients, reduce the incidence of adverse reactions and exert better sedation and anesthesia effects.