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目的:观察甲基强的松龙(methylprednisolone,MP)对活动期多发性硬化(active multiple sclerosis,AMS)血清细胞因子网络的影响。方法:AMS台疗前、静滴(1g·d~(-1))3 d后即刻、24、96 h留取静脉血。检测白细胞介素-1β(interleukin-1β、IL-1β)、IL-2、IL-4和肿瘤坏死因子-a(tumor necorsis factor-a,TNF-a)、IL-10和干扰素γ(interferon-γ,IFN-γ)。结果:治疗前,AMS血清IL-1β、IL-2及IL-10较正常组显著升高(P<0.005,P=0.001,P=0.012),IL-4浓度和正常对照组相似。治疗后,血清IL-1β、IL-2、浓度比治疗前显著降低(P均<0.001),并有逐渐减低的趋势,IL-10浓度逐渐升高,但无统计学意义(P>0.05),IL-4比治疗前显著升高(P<0.05)。结论:MP可能通过调节AMS细胞因子网络中前炎性(TH1)和抗炎性(TH2)细胞因子来抑制TH1细胞的免疫应答。
Objective: To observe the effect of methylprednisolone (MP) on serum cytokine network in active multiple sclerosis (AMS). Methods: AMS immediately before intravenous infusion (1g · d ~ (-1)) immediately after 3 d, 24,96 h to take venous blood. The levels of interleukin-1β (IL-1β), IL-2, IL-4 and tumor necrosis factor-a (TNF-a), IL-10 and interferon -γ, IFN-γ). Results: Before treatment, the levels of IL-1β, IL-2 and IL-10 in AMS serum were significantly higher than those in normal group (P <0.005, P = 0.001, P = 0.012). After treatment, the levels of IL-1β and IL-2 in serum were significantly lower than those before treatment (all P <0.001), and gradually decreased. The concentration of IL-10 gradually increased but there was no statistical significance (P> 0.05) , IL-4 was significantly higher than before treatment (P <0.05). Conclusion: MP may inhibit the immune response of TH1 cells by regulating the pro-inflammatory (TH1) and anti-inflammatory (TH2) cytokines in the AMS cytokine network.