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目的对宫颈癌放疗实际敏感性临床病理相关影响因素予以探讨分析。方法 88例病理确诊宫颈癌患者作为研究对象,对其放疗相关临床资料给予回顾性分析进而确定临床病理相关影响因素。结果年龄:<45岁,完全缓解21例,未控2例,年龄≥45岁,完全缓解60例,未控5例。肿瘤直径:<4 cm,完全缓解40例,未控3例,≥4 cm,完全缓解41例,未控4例。肿瘤形态:1菜花型:完全缓解39例,未控3例;2结节型:完全缓解35例,未控3例;3溃疡型:完全缓解7例,未控1例;临床分期:1Ⅰ期:完全缓解5例,未控0例;2Ⅱ期:完全缓解9例,未控5例;3Ⅲ期:完全缓解58例,未控2例;4Ⅳ期:完全缓解9例,未控0例。病例类型:1鳞癌:完全缓解63例,未控3例;2腺癌:完全缓解13例,未控2例;3鳞腺癌:完全缓解5例,未控0例。分化程度高,完全缓解6例,未控0例,分化程度中低,完全缓解72例,未控7例。患者年龄及临床分期与其宫颈癌病症放疗方面敏感性无关(P>0.05),而患者肿瘤直径及肿瘤形态和相应分化程度、病理类型与其宫颈癌病症放疗方面敏感性有关(P<0.05)。结论对于宫颈癌患者而言影响其放疗实际敏感性的相关病理因素集中在肿瘤直径及肿瘤形态和相应分化程度、病理类型四方面。
Objective To investigate the clinical and pathological factors related to the actual sensitivity of radiotherapy to cervical cancer. Methods Eighty - eight patients with pathologically diagnosed cervical cancer were enrolled in this study. The clinical data of radiotherapy were retrospectively analyzed to determine the influencing factors of clinicopathology. Results Age: <45 years, complete remission in 21 cases, uncontrolled in 2 cases, age ≥ 45 years, complete remission in 60 cases, uncontrolled in 5 cases. Tumor diameter: <4 cm, complete remission in 40 cases, uncontrolled in 3 cases, ≥ 4 cm, complete remission in 41 cases, 4 cases were not controlled. Tumor morphology: 1 cauliflower type: complete remission in 39 cases, 3 cases not controlled; 2 nodules: complete remission in 35 cases, 3 cases were not controlled; 3 ulcer type: complete remission in 7 cases, 1 case not controlled; clinical stage: 1 Stage 2: complete remission in 9 cases, uncontrolled in 5 cases; Stage 3: complete remission in 58 cases, uncontrolled in 2 cases; Stage 4Ⅳ: complete remission in 9 cases, uncontrolled in 0 cases; . Case type: 1 squamous cell carcinoma: complete remission in 63 cases, 3 cases not controlled; 2 adenocarcinoma: complete remission in 13 cases, 2 cases were not controlled; 3cancer adenocarcinoma: complete remission in 5 cases, 0 cases not controlled. High degree of differentiation, complete remission in 6 cases, 0 cases were not controlled, low differentiation, complete remission in 72 cases, 7 cases were not controlled. The age and clinical stage of the patients were not related to the radiosensitivity of cervical cancer (P> 0.05). The diameter of the tumor, the shape of the tumor, the corresponding degree of differentiation and the pathological type were related to the radiosensitivity of cervical cancer (P <0.05). Conclusions The relevant pathological factors affecting the actual sensitivity of radiotherapy to cervical cancer patients are concentrated in four aspects: the diameter of the tumor, the shape of the tumor, the corresponding degree of differentiation and the pathological type.