论文部分内容阅读
为探讨膜增殖性肾炎临床与病理的关系,对17例经肾活检证实的病儿进行分析。结果:男12例,女5例;平均年龄9.4岁;平均病程1.5年。肾活检结果:Ⅰ型14例,Ⅱ型3例。17例均有免疫球蛋白沉积。5例同时有补体C3沉积。11例采用泼尼松隔日长程疗法,6例泼尼松+CTX冲击。平均随访3.6年。完全缓解6例,无好转5例,肾功能减退4例,失访2例。提示本病治疗困难,预后不佳,肾活检是确诊的主要手段,甲基强的松龙疗法值得倡用。
To investigate the relationship between the clinical and pathological changes of proliferative glomerulonephritis, 17 cases of children confirmed by renal biopsy were analyzed. Results: There were 12 males and 5 females with an average age of 9.4 years and a mean duration of 1.5 years. Kidney biopsy results: 14 cases of type Ⅰ, 3 cases of type Ⅱ. 17 cases of immunoglobulin deposition. Five patients also had complement C3 deposition. Eleven patients received long-term therapy with prednisone every other day and 6 patients received prednisone + CTX. The average follow-up 3.6 years. Complete remission in 6 cases, no improvement in 5 cases, 4 cases of renal dysfunction, lost 2 cases. Prompt treatment of this disease is difficult, poor prognosis, renal biopsy is the main means of diagnosis, methyl prednisolone therapy is worth promoting.