论文部分内容阅读
目的:探讨肝郁证(肝气郁结证)患者欣赏悲伤音乐时血氧水平依赖脑功能磁共振成像(BOLD-f MRI)的激活模式,从影像学角度揭示肝郁证的病理生理机制。方法:选择确诊的肝郁证患者16例,均为典型单纯肝郁证、无其他兼证夹杂患者。对照组16例。实验方法采用组块设计,所有受试者欣赏悲伤音乐同时,用BOLD-f MRI技术进行脑功能磁共振成像,经统计学处理后获取激活脑区,比较肝气郁结证和正常人群对悲伤音乐激活脑区的差异。结果:肝郁证组在欣赏悲伤音乐时显著激活了右侧额中回、左侧额上回、左侧额中回、左侧顶下小叶及左侧扣带回。左侧半球激活脑容积显著大于右侧。正常对照组激活脑区主要包括双侧额中回、左侧顶下小叶、双侧扣带回、双侧海马旁回、双侧楔叶等。肝郁证激活脑区范围较对照组显著减少。结论:研究发现肝郁证患者和正常人群欣赏悲伤音乐时脑区激活模式存在显著差异,从而进一步证实肝郁证脑功能异常模式,为肝郁证所致脑功能改变提供了客观依据。
OBJECTIVE: To explore the activation mode of blood oxygen level dependent on brain-function magnetic resonance imaging (BOLD-f MRI) in patients with liver depression syndrome (liver qi stagnation syndrome), and to reveal the pathophysiological mechanism of liver depression syndrome from the imaging point of view. Methods: Sixteen patients with confirmed liver depression syndrome were selected, all of which were typical pure liver depression syndromes. There were no other complicated syndromes. Control group of 16 cases. Experimental methods using block design, all subjects enjoy sad music at the same time, using BOLD-f MRI brain functional magnetic resonance imaging, after the statistical treatment of activated brain area, liver depression syndrome and the normal population of sad music activation Differences in brain regions. Results: The group of liver depression syndrome activated the right middle frontal gyrus, the upper left frontal gyrus, the middle frontal gyrus, the left inferior parietal lobule and the left cingulate gyrus when enjoying sad music. The left hemisphere activated brain volume was significantly greater than the right side. Normal control group activated brain areas include bilateral frontal gyrus, left top of the leaflets, bilateral cingulate gyrus, bilateral parahippocampal gyrus, bilateral wedge leaf and so on. The area of brain activation activated by liver depression was significantly reduced compared with the control group. Conclusion: The study found that there is a significant difference in brain activation patterns between patients with liver depression and normal people when they enjoy sad music, which further confirms the pattern of abnormal brain function in patients with liver depression and provides an objective basis for the changes of brain function caused by liver depression syndrome.