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【目的】观察血浆大内皮素1与 D‐二聚体联合检测对预测急性缺血性脑卒中（AIS）再出血的应用价值。【方法】选择2013年6月至2015年3月于本院接受治疗的80例 AIS 患者为研究对象，出院后对其进行为期6个月的随访。观察出院后再出血的发生情况，分析影响 AIS 患者再出血的因素，探讨血浆大内皮素1与 D‐二聚体联合检测对再出血的预测价值。【结果】单因素分析结果表明：年龄≥65岁、合并高血压、合并冠心病、血脂异常的急性缺血性脑卒中患者再出血的发生率较高，差别具有统计学意义（ P ＜0．05）；年龄≥65岁、发生再出血、合并高血压、合并冠心病和血脂异常的患者大内皮素和 D‐二聚体水平较高（ P ＜0．05）；Logistic 多因素回归分析表明：年龄、合并高血压、血脂异常、大内皮素1和 D‐二聚体高水平是患者发生再出血的危险因素；大内皮素1与 D‐二聚体预测 AIS 再出血的灵敏度为46．56％，特异度和准确度分别为77．48％和58．56％。【结论】血浆大内皮素1与 D‐二聚体与 AIS 患者再出血密切相关，对疾病的预测有重要的临床价值。“,”Objective]To explore the clinical value of the combined detection of plasma endothelin 1 and D‐dimer on the prediction of re‐bleeding of acute ischemic stroke (AIS) .[Methods]A total of 80 cases of pa‐tients with AIS treated in our hospital from June 2013 and March 2015 were selected as the object .They were followed up for a period of 6 months after discharge .The occurrence of re‐bleeding after discharge was ob‐served ,the factors of re‐bleeding in acute ischemic stroke patients were analyzed ,and the predictive value of the joint detection of plasma endothelial element 1 and D‐dimer on re‐bleeding was studied .[Results]Univari‐ate analysis showed that the incidence of re‐bleeding was higher in patients who were of age 65 or older and with hypertension ,coronary heart disease ,and lipid abnormality ;the difference had statistical significance ( P< 0 .05) .The levels of endothelial element 1 and D‐dimer were significantly higher in patients who were of age 65 or older ,experienced re‐bleeding ,and with hypertension ,coronary heart disease ,and abnormal blood lip‐id ;the difference had statistical significance ( P < 0 .05) .Logistic regression analysis showed that age ,hyper‐tension ,dyslipidemia ,and levels of endothelial 1 and D ‐ dimer were the risk factors of re‐bleeding .The sensi‐tivity of the prediction of re‐bleeding of AIS through endothelial prime 1 and D ‐ dimer was 46 .56% ;specificity and accuracy were 77 .48% and 58 .56% ,respectively .[Conclusion] Levels of endothelial 1 and D ‐ dimer are closely related to re‐bleeding in AIS and have important clinical value in the prediction of the disease .