以2,9-二甲基-1,10-菲咯啉为初始原料,合成了1,10-菲咯啉的l-缬氨酸衍生物——1,10-菲咯啉-2,9-二亚甲基亚氨基-(2,2＇-二异丙基)二乙酸(L).该配体经过元素分析、红外光谱、核磁共振氢谱表征.通过电子光谱,研究了La(Ⅲ)的配合物与小牛胸腺DNA的相互作用.用溴化乙锭作为荧光探针,还研究了La(Ⅲ)-L配合物与小牛胸腺DNA的相互作用的过程.作为对比,也研究了La(Ⅲ)分别与1,10-菲咯啉(Phen)、l-缬氨酸(Val)的配合物与小牛胸腺DNA的相互作用.结果表明La(Ⅲ)-L配合物与小牛胸腺DNA作用既有共价键合,又有插入作用. Using 2,9-dimethyl-1,10-phenanthroline as the starting material, 1,10-phenanthroline-1,9 (2,2’-diisopropyl) diacetic acid (L). The ligand was characterized by elemental analysis, FTIR and 1HNMR. The electronic spectra of La ) Complexes with calf thymus DNA. The interaction of La (III) -L complex with calf thymus DNA was also studied using ethidium bromide as a fluorescent probe. As a comparison, The interaction between La (Ⅲ) and 1,10-phenanthroline (L-valine) and calf thymus DNA was investigated. The results showed that La (Ⅲ) Bovine thymus DNA both the role of covalent bonding, but also insert.