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目的探讨老年急性心梗患者溶栓治疗后ＱＴｃ间期的变化。方法将老年ＡＭＩ患者分为溶栓组（２３例）和未溶栓组（２５例），用Ｂａｚｅｔ′ｓ公式计算ＱＴｃ并进行ｔ检验或秩和检验。结果两组患者发病后ＱＴｃ间期平均值均延长，两组比较无统计学差异。溶栓组溶栓后１ｄＱＴｃ间期明显延长；第２日达高峰后迅速缩短，而未溶栓组发病后１～３ｄＱＴｃ间期无明显变化；从发病第４日起缓慢缩短。溶栓所致的ＱＴｃ间期延长可能与缺血后再灌注损伤有关。比较两组不同时间的ＱＴｃ间期除溶栓后第２日有统计学差异外，其余均无统计学差异。而比较两组不同时间的ＱＴｃ间期变化均有统计学差异。结论评价老年ＡＭＩ患者溶栓疗效时，比较ＱＴｃ间期缩短的速度比单纯比较溶栓后某时间ＱＴｃ间期意义更大。
Objective To investigate the changes of QTc after thrombolysis in elderly patients with acute myocardial infarction. Methods The elderly AMI patients were divided into thrombolysis group (23 cases) and no thrombolysis group (25 cases). QTc was calculated by Bazet’s formula and t test or rank sum test was used. Results The average QTc interval after the onset of the two groups were prolonged, there was no significant difference between the two groups. Thrombolytic group 1dQTc after prolongation significantly prolonged; the second day after the peak rapidly shortened, but did not thrombolytic group 1 ~ 3dQTc after the onset of no significant change; from the onset of the first 4 days slowed down. QTc prolongation caused by thrombolysis may be related to ischemia-reperfusion injury. There was no significant difference in the QTc interval between the two groups except the second day after thrombolytic therapy. The QTc interval changes between the two groups were statistically different. Conclusion When evaluating thrombolysis in elderly patients with AMI, the QTc interval shortening rate is more significant than the QTc interval after a simple comparison of thrombolysis.