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近年,抗精神分裂症药物联合使用有日益增加的趋势。本文现对氯氮平、奥氮平与其他抗精神分裂药物联合使用的疗效与安全性作一简要回顾。氯氮平和舒必利联用有较肯定的疗效,但可致血清催乳素水平升高或锥体外系反应加剧。氯氮平和氨磺必利联用患者病情似可全面改善,但可致血清催乳素水平升高。氯氮平和利培酮联用的临床疗效和安全性试验显示不同的结果。奥氮平和其他某些典型抗精神病药联用治疗效果有所增强。奥氮平与利培酮联用似有助于改善难治性精神分裂症患者症状。笔者认为应对这些联用的利弊作进一步的评估,以利于合理安全用药。
In recent years, the combination of anti-schizophrenia drugs have an increasing trend. This article now clozapine, olanzapine and other anti-schizophrenic drugs combined with the efficacy and safety of a brief review. Clozapine and sulpiride combined with a more positive effect, but can lead to elevated serum prolactin levels or extrapyramidal reactions. Clozapine and amisulpride combined with the patient’s condition seems to be fully improved, but can cause serum prolactin levels. Clinical efficacy and safety trials of clozapine and risperidone showed different results. Olanzapine and some other typical antipsychotics have been treated in combination. Olanzapine and risperidone may help to improve the symptoms of refractory schizophrenia. I believe that the pros and cons of these combinations should be further assessed in order to facilitate rational and safe medication.