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以结合反应为特征的Ⅱ相药物代谢是机体处置药物重要环节,主要包括葡萄糖醛酸化、乙酰化、甲基化、谷胱甘肽化、硫酸化等结合反应。不同基团对应的结合反应均由多个同类基因或超基因家族介导催化完成。Ⅱ相代谢反应都具有各自不同的反应特征与各自不同的功能意义。Ⅱ相药物代谢酶活性受联合用药影响会导致临床药物相互作用,其基因多态性一方面会影响内源性物质的代谢,可能导致某些疾病发生率升高,同时也会影响外源性物质的代谢,引起药物疗效的改变或毒性反应的发生。
Phase II drug metabolism characterized by the binding reaction is an important part of the body’s handling of drugs, including glucuronidation, acetylation, methylation, glutathione, sulfation and other binding reactions. Different groups corresponding to the binding reaction by a number of similar genes or super-gene family mediated catalytic completion. Phase Ⅱ metabolic reactions have their own different reaction characteristics and their different functional meanings. Phase II drug metabolism enzyme activity by the combination of drugs will lead to clinical drug interactions, the genetic polymorphism will affect the metabolism of endogenous substances on the one hand, may lead to an increase in the incidence of certain diseases, but also affect the exogenous Material metabolism, causing changes in the efficacy of drugs or the occurrence of toxic reactions.