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目的:探讨急性早幼粒细胞白血病(M3)中枢神经系统(CNS)复发的风险因素。方法:回顾性观察15例M3病情完全缓解后出现CNS复发的WBC总数、外周血幼稚细胞百分比、骨髓完全缓解所需时间。结果:WBC≥50×109/L、幼稚细胞≥50 %及骨髓完全缓解所需时间>1个月者,更易发生CNS浸润(P值均<0.05)。结论:WBC计数、外周血幼稚细胞百分比、骨髓完全缓解时间对预测M3在CNS复发有临床指导意义。
Objective: To investigate the risk factors of recurrent central nervous system (CNS) in acute promyelocytic leukemia (M3). Methods: The total number of WBCs, the percentage of naive cells in peripheral blood and the time required for complete remission of bone marrow after CNS relapse were retrospectively observed in 15 patients with complete remission of M3. Results: CNS infiltration was more likely to occur in patients with WBC≥50 × 109 / L, naive cells ≥50%, and bone marrow required for complete remission for> 1 month (P all <0.05). CONCLUSION: The WBC count, the percentage of naive cells in peripheral blood and the time to complete remission of bone marrow are of clinical significance in predicting the recurrence of M3 in the CNS.