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目的:评价实验室快速检测技术联合临床对结核病患病可能性的早期诊断。方法:依据临床对结核病患病可能性程度的判断将患者分为高、低2组,收集患者痰液标本,同时进行涂片抗酸染色法、荧光定量PCR法和培养法检测,根据最终诊断对不同患病可能性患者的检查结果进行分析。结果:确诊肺结核患者25例;高可能性组涂片抗酸染色法、荧光定量PCR法和培养法阳性率分别为21.43%、28.57%和30.36%,与低可能性组比较差异有统计学意义(P<0.05)。高可能性组涂片抗酸染色法和荧光定量的敏感性、特异性、阳性预测值和阴性预测值均优于低可能性组。结论:将结核病实验室检测技术与临床对患病可能性的判断相结合,可提高诊断肺结核的准确性。
Objective: To evaluate the rapid diagnosis of tuberculosis by laboratory rapid detection technology combined with clinical diagnosis of early diagnosis. Methods: According to the clinical judgment of the possibility of tuberculosis, the patients were divided into high and low groups. The sputum samples of patients were collected. Meanwhile, smear anti-acid staining method, fluorescence quantitative PCR method and culture method were used. According to the final diagnosis Analysis of the test results of patients with different possibility of illness. Results: Twenty-five patients were diagnosed as pulmonary tuberculosis. The positive rate of smear anti-acid staining, fluorescence quantitative PCR and culture in high probability group were 21.43%, 28.57% and 30.36%, respectively, which were significantly different from the low probability group (P <0.05). Sensitivity, specificity, positive predictive value, and negative predictive value of high probability smear antacid staining and fluorescence quantification were all better than low probability smear group. CONCLUSIONS: Combining TB laboratory testing techniques with clinical judgment of the likelihood of illness can improve the accuracy of TB diagnosis.