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目的:观察a干扰素联合甘利欣治疗慢性乙型肝炎的疗效。方法:治疗组予a干扰素500万U单位,肌注,1次/d×30 d;后改为隔日1次,总疗程为6个月,同时口服甘利欣胶囊150 mg,3次/d,疗程为6个月。对照组采用干扰素,剂量方法同前。治疗前后分别检测ALT、HBV-DNA、HBeAg、抗-HBc。一年后分别测定两组的HBV-DNA、HBeAg复阳率。结果:治疗组治愈率和显效率、ALT复常率、HBV-DNA、HBeAg阴转率及抗-HBc转阴率均较对照组明显增高;治疗1年后治疗组患者血清HBeAg和HBV-DNA复阳率较对照组明显下降。结论:a干扰素联合甘利欣治疗慢性乙肝近期和远期疗效好,复发率低。
Objective: To observe the efficacy of a interferon combined with glycyrrhizin in the treatment of chronic hepatitis B. Methods: The treatment group received 5 million units of interferon-α, intramuscularly, once per day for 30 days, then changed to every other day for a total of 6 months. At the same time, oral administration of Glycyrrhizin capsules was 150 mg for 3 times daily , Course of treatment is 6 months. Control group using interferon, the same dose method. Before and after treatment were detected ALT, HBV-DNA, HBeAg, anti-HBc. One year later, the levels of HBV DNA and HBeAg were measured in two groups respectively. Results: The cure rate, effective rate of ALT, ALT normalization rate, HBV-DNA, HBeAg negative conversion rate and anti-HBc conversion rate were significantly higher in the treatment group than those in the control group. Serum HBeAg and HBV-DNA Complex positive rate decreased significantly compared with the control group. Conclusion: Interferon-a combined with Gan Lixin treatment of chronic hepatitis B short-term and long-term efficacy, low recurrence rate.