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目的探讨老年糖尿病患者合并腔隙性脑梗死的临床特点及相关危险因素。方法选择60例老年糖尿病合并腔隙性脑梗死患者为观察组,56例非糖尿病腔隙性脑梗死患者为对照组,比较两组一般情况、检查指标以及NIHSS评分。结果观察组TG、LDL-C、FIB、Apo B及多发腔隙性脑梗死比例高于对照组,差异有统计学意义(P<0.05)。NIHSS评分情况在首次接诊两组患者差异无统计学意义(P>0.05),而在6个月时,对照组NIHSS>15分的比例(58.9%)明显高于观察组(45.0%),差异无统计学意义(P>0.05),Logistic多因素回归分析,LDL-C、Apo B是独立危险因素,而FIB水平不是独立危险因素。结论老年糖尿病腔隙性脑梗死患者具有更高的血脂水平、收缩压以及FIB等,同时更容易发生多发性腔隙性脑梗死,而在预后上则要稍微差于非糖尿病腔隙性脑梗死患者,同时LDL-C、Apo B是糖尿病腔隙性脑梗死的独立危险因素。
Objective To investigate the clinical features and related risk factors of elderly patients with diabetes mellitus complicated with lacunar infarction. Methods Sixty elderly patients with diabetes mellitus complicated with lacunar infarction were selected as observation group and 56 patients with non-diabetic lacunar infarction as control group. The general conditions, the indexes of examination and the NIHSS score were compared between the two groups. Results The proportion of TG, LDL-C, FIB, Apo B and multiple lacunar infarction in the observation group was higher than that in the control group, with statistical significance (P <0.05). There was no significant difference in NIHSS score between the two groups (P> 0.05). At 6 months, the NIHSS score> 15 (58.9%) in the control group was significantly higher than that in the observation group (45.0%), There was no significant difference (P> 0.05). Logistic regression analysis showed that LDL-C and Apo B were independent risk factors, while FIB level was not an independent risk factor. Conclusions Patients with lacunar diabetes with cerebral infarction have higher serum lipids, systolic blood pressure and FIB, and are more likely to have multiple lacunar infarctions, while their prognosis is slightly lower than that of non-diabetic lacunar infarcts Patients, while LDL-C, Apo B is an independent risk factor for lacunar infarction in diabetes.