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目的探讨≥70岁手术切除的老年人肺癌病例的临床特点及影响预后的因素。方法采用STA-TA5.0统计软件建立病例资料数据库并进行统计分析,生存率用寿命表法计算,生存率差异的显著性试验用Lo-grank检验。结果本组周围型病变占92.2%,术后并发症发生率为15.1%,术后30天内死亡率1.9%。5年生存率:根治术49.7%,高于姑息术15.0%(P<0.05);腺癌45.1%高于鳞癌20.9%(P<0.05);TNM分期中Ⅰ期51.9%、Ⅱ期28.6%及Ⅲa期20.1%。在姑息术中,综合治疗组的5年生存率33.0%、单纯手术组无5年生存者(P>0.05)。在Ⅲa期病例中,综合治疗组的5年生存率23.8%、单纯手术组14.6%(P>0.05)。结论腺癌预后显著地优于鳞癌,周围型病变、姑息性切除术、部分肺叶切除术及术后并发症的比例高是本组老年人肺癌的特点。手术性质显著地影响生存。对姑息术及Ⅲa期病人综合治疗可提高生存,但无统计学差异
Objective To investigate the clinical features and the factors that influence the prognosis of elderly patients with ≥ 70 years old lung cancer. Methods STA-TA5.0 statistical software was used to establish a database of case data and statistical analysis was performed. The survival rate was calculated using the life table method. The significant difference of survival rate was tested by Lo-grank test. Results Peripheral lesions in this group accounted for 92.2%, the incidence of postoperative complications was 15.1%, mortality was 1.9% within 30 days after surgery. The 5-year survival rate was 49.7% for radical surgery, which was 15.0% higher than palliative surgery (P<0.05); 45.1% for adenocarcinoma was higher than 20.9% for squamous cell carcinoma (P<0.05); In the TNM stage, 51.9% of phase I, 28.6% of phase II, and 20.1% of phase IIIa. In palliative surgery, the 5-year survival rate of the combined treatment group was 33.0%, and the surgery group had no 5-year survival (P>0.05). In stage IIIa cases, the 5-year survival rate was 23.8% in the combined treatment group and 14.6% in the simple surgery group (P>0.05). Conclusion The prognosis of adenocarcinoma is significantly better than that of squamous cell carcinoma. Peripheral lesions, palliative resection, partial lobectomy, and high proportion of postoperative complications are characteristic of lung cancer in this group of elderly patients. The nature of the surgery significantly affects survival. Combined therapy for palliative surgery and stage IIIa patients can improve survival, but there is no statistical difference