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凝固血液于无菌条件下发生自发性溶解的現象称为纤維蛋白溶解(fibrinolysis以下簡称纤溶)。这名称是1893年Dastre氏提出的。近年来Roseman、MacFarlane氏等証明这种現象是血浆中特殊蛋白溶酶受多种因素激活所致,MacFarlane氏等将此溶酶分离出来,称为血浆素(plasmin)或纤維蛋白溶酶(fibrinolysin)。此种溶酶的酶元可在各种生理或病理状态下被激活,它在人体血浆中的浓度一旦完全被激活,在几分钟內足以使全身的纤維蛋白元溶解。最近,有关纤溶的报告屡見不鮮,本文仅就近年来有关内科临床方面的研究加以綜述。
Coagulation of blood under sterile conditions spontaneous dissolution of the phenomenon known as fibrinolysis (fibrinolysis hereinafter referred to as fibrinolysis). This name was proposed by Dastre in 1893. In recent years, Roseman, MacFarlane’s and other evidence that this phenomenon is due to the activation of a variety of special plasma plasminogen factors, MacFarlane et al the separation of this lytic enzyme, called plasmin or fibrinolysin (fibrinolysin ). Enzymes of this lysosomal enzyme can be activated under various physiological or pathological conditions, and once it is completely activated in human plasma, it is sufficient to dissolve the whole body of fibrin within a few minutes. Recently, the report on fibrinolysis is not uncommon, this article only in recent years, clinical aspects of medical research to be reviewed.