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目的 通过检测P2 7Kipl及Ki 6 7抗原在结 (直 )肠腺瘤、腺癌中的表达 ,探讨其与临床病理指标及预后的关系。方法 采用免疫组织化学方法检测了 2 0例正常结 (直 )肠粘膜、16例腺瘤、6 2例腺癌的P2 7Kipl及Ki 6 7抗原的表达。结果 正常粘膜、腺瘤至腺癌的等级与P2 7Kipl表达等级呈负相关 ,而与Ki 6 7抗原表达等级呈正相关。腺瘤与腺癌细胞质P2 7Kipl表达有显著性差异 (P <0 .0 5 )。腺癌组P2 7Kipl表达与Ki 6 7抗原表达、肿瘤有无转移、Dukes’分期及国际TNM分期呈负相关 ;Ki 6 7抗原表达与有无转移呈正相关。P2 7Kipl表达阳性腺癌患者无病生存时间长于表达阴性者。结论 在结 (直 )肠肿瘤的发生、发展及转移过程中 ,P2 7Kipl表达下调 ,Ki 6 7抗原表达上调 ;P2 7Kipl表达对评估结 (直 )肠癌患者预后有一定帮助。
Objective To investigate the relationship between the expression of P2 7 Kip1 and Ki 6 7 in colorectal adenoma and adenocarcinoma, and to explore its relationship with the clinicopathological parameters and prognosis. Methods Immunohistochemistry was used to detect the expression of P2 7 Kip1 and Ki 6 7 in 20 normal colorectal mucosa, 16 adenomas and 62 adenocarcinomas. Results The grades of normal mucosa, adenoma to adenocarcinoma were negatively correlated with the P2 7 Kip1 expression level, but positively correlated with the Ki 6 7 antigen expression grade. The expression of P2 7Kip1 in adenoma and adenocarcinoma was significantly different (P <0.05). The expression of P2 7 Kip1 in adenocarcinoma was negatively correlated with the expression of Ki 6 7 antigen, tumor metastasis, Dukes’ staging and international TNM staging. Ki 6 7 antigen expression was positively correlated with metastasis. Patients with positive P2 7Kip1 expression had longer disease-free survival than those with negative expression. Conclusion The expression of P2 7 Kip1 is down-regulated and the expression of Ki 6 7 is up-regulated during the development, progression and metastasis of junctional (colorectal) neoplasms. The expression of P2 7 Kipl may help to evaluate the prognosis of patients with colorectal neoplasms.