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目的:采用系统评价的方法综合分析DNA修复基因(X-ray cross-complementing group 1,XRCC1)26304C>T位点单核苷酸多态性与口腔癌易感性的关系。方法:检索PubMed(1966～2011.4)、EMBASE(1974～2011.4)、中国生物医学文献数据库CBM(1978～2011.3)、中国期刊全文数据库CNKI(1994～2011.3)等数据库收录的XRCC1-26304C>T单核苷酸多态性与口腔癌易感性的研究。以病例组和对照组等位基因分布的比值比(odds ratio OR)为效应指标,根据异质性检验结果,选择固定效应模型或随机效应模型对OR进行合并。结果:本次meta分析共纳入文献7篇,病例组1155例,对照组2036例。分析结果显示:突变纯合子(T/T)患口腔癌的风险与野生型纯合子(C/C)相比OR=1.46(0.93～2.28);隐性模式下,突变纯合子(T/T)患口腔癌的风险与野生型(纯合子+杂合子)(C/C)+(C/T)相比OR=1.30(0.84～2.00);显性模式下,突变个体(突变纯合子+突变杂合子)(T/T)+(C/T)患口腔癌的风险与野生型纯合子(C/C)相比OR=1.34(1.02～1.76)。按亚洲人群和高加索人群进行亚组分析,亚洲人群在显性模式下该位点的多态性与口腔癌易感性存在相关性OR=1.42(1.04～1.94),其它情况下均未发现相关性。结论:显性模式下携带XRCC1基因突变型(TT+CT)的亚洲人可能是口腔癌的易感人群,但需要更多的研究加以证实。
OBJECTIVE: To systematically analyze the relationship between single nucleotide polymorphism at 26304C> T site of X-ray cross-complementing group 1 (XRCC1) and the susceptibility to oral cancer using systematic evaluation. Methods: The sequences of XRCC1-26304C> T mononuclear cells from PubMed (1966 ~ 2011.4), EMBASE (1974 ~ 2011.4), CBM from China Biomedical Literature Database (1978 ~ 2011.3) and CNKI (1994 ~ 2011.3) Study on Polymorphisms of Glycine max and Oral Cancer. The odds ratio (OR) of allele distribution in case group and control group was taken as the effect index. According to the results of heterogeneity test, the fixed effect model or random effect model was selected to combine OR. Results: A total of 7 articles were included in this meta-analysis, including 1155 cases and 2036 cases in the control group. The results showed that the risk of oral cancer with mutant homozygote (T / T) was 1.46 (0.93 ~ 2.28) compared with that of wild type homozygote (C / C) ) OR = 1.30 (0.84-2.00) compared with wild-type (homozygote + heterozygous) (C / T); and in dominant mode, the mutation individuals (mutant homozygote + Mutation heterozygote) (T / T) + (C / T) OR = 1.34 (1.02-1.76) compared with wild-type homozygotes (C / C) According to the subgroup analysis of Asian population and Caucasians, there was a significant correlation between polymorphism in Asian population and oral cancer susceptibility (OR = 1.42 (1.04-1.94)) in other populations . CONCLUSIONS: Asians carrying the XRCC1 mutant (TT + CT) in dominant mode may be susceptible to oral cancer, but more studies are needed to confirm this.