目的　观察碱性成纤维细胞生长因子 (basicfibroblastgrowthfactor ,bFGF)对庆大霉素所致活体豚鼠前庭损害的保护作用。方法　豚鼠皮下注射庆大霉素连续 10天 ,造成内耳损伤。实验组同时腹腔注射bFGF ,对照组则注射生理盐水。检测两组豚鼠的前庭功能 ,前庭终器行扫描电镜观察。结果　对照组前庭损伤明显重于实验组。结论　bFGF对庆大霉素所致活体豚鼠前庭损害有保护作用 Objective To observe the protective effect of basic fibroblast growth factor (bFGF) on the damage of guinea pig vestibules induced by gentamicin. Methods Guinea pigs injected gentamicin subcutaneously for 10 consecutive days, resulting in damage to the inner ear. The experimental group was injected intraperitoneally with bFGF, while the control group was injected with saline. The vestibular function of two groups of guinea pigs was examined and the vestibular terminal line was observed by scanning electron microscopy. Results The vestibular injury in the control group was significantly heavier than that in the experimental group. Conclusion bFGF has a protective effect on guinea pig vestibules induced by gentamicin