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第10号染色体缺失的磷酸酶张力蛋白同源物基因(phosphatase and tensin homology deleted on chromosome ten，PTEN)的异常表达与多种恶性肿瘤密切相关，并通过抑制P13K/AKT信号通路的活性来调节细胞的增殖、存活和代谢。PTEN在肿瘤中所起的作用早已被人们所熟知，但近几年来，研究者发现PTEN的失活会导致免疫细胞如T、B细胞的过度活化，进而促进自身免疫性疾病的发展。现就近年来PTEN在类风湿性关节炎、系统性红斑狼疮、系统性硬化症等自身免疫性疾病中的研究现状做一综述。“,”The abnormal expression of phosphatase tensin homologous protein(PTEN) gene missing from chromosome 10 is closely related to many kinds of malignant tumors. This gene regulates cell proliferation, survival and metabolism by inhibiting the activity of P13K/AKT signaling pathway. The role of PTEN in tumor has been known for a long time, but in recent years, researchers have found that the inactivation of PTEN will lead to over activation of immune cells such as T and B cells, and then promote the development of autoimmune diseases. This paper reviews the research status of PTEN in rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis and other autoimmune diseases in recent years.