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目的 定量的考察姜黄素与α ,β ,γ 环糊精及一系列有机硒桥连双环糊精的键合能力与包结配位行为。 方法 采用紫外 可见光谱滴定法测定了姜黄素在 2 5℃时 ,pH =2 .0缓冲溶液中与主体分子 1～ 6形成 1∶1超分子配合物的稳定常数(Ks)及吉布斯自由能 (ΔG°)。结果 β 环糊精对姜黄素的键合能力明显高于α ,与γ 环糊精。与母体环糊精相比 ,具有功能桥链的有机硒桥连双环糊精通过相邻的两个环糊精空腔对一个姜黄素分子的协同键合 ,能够明显的扩展母体环糊精原有的键合能力 ,给出了比 β 环糊精高 2 .8～ 17.1倍的稳定常数。 结论 尺寸 形状匹配及主客体间的疏水相互作用是影响主体 1～ 6与姜黄素的键合能力和包结配位行为的关键因素
Objective To quantitatively investigate the binding ability and the inclusion-coordination behavior of curcumin with α, β, γ-cyclodextrin and a series of organic selenide bridging bicyclodextrins. Methods The stability constants (Ks) of 1:1 supramolecular complexes with host molecules 1 to 6 in buffer solution of pH=2.0 in curcumin at 25 °C were determined by UV-Vis spectroscopy titration and Gibbs free. Energy (ΔG°). Results The binding ability of β-cyclodextrin to curcumin was significantly higher than that of α and γ-cyclodextrin. Compared with the parent cyclodextrin, the organic selenide bridged bicyclodextrin with a functional bridge chain can significantly expand the parent cyclodextrinogen through the cooperative bonding of a curcumin molecule through two adjacent cyclodextrin cavities. Some bonding ability gives a stability constant of 2.8 to 17.1 times higher than that of β-cyclodextrin. Conclusion Dimensional shape matching and hydrophobic interactions between host and guest are the key factors influencing the bonding ability and inclusion coordination behavior of host 1～6 and curcumin