博莱霉素一直被认为是一种对免疫反应没有任何作用的药物.然而本文作者报告,在特定情况下,它可以增强豚鼠对2,4-二硝基氟苯(DNFB)的皮肤敏感性;增加皮肤致敏处区域淋巴结中T-淋巴细胞的增殖.作者用经过DNFB致敏的Hartley杂系豚鼠进行皮肤试验.将浓度为0.1%、0.25%、0.5%的DNFB溶液滴在刮过毛的豚鼠侧腹,于24、48、72、96小时记录皮肤反应.反应强度分为3级:3级皮肤红肿;2.5级皮肤红 Bleomycin has long been considered a drug that has no effect on the immune response However, the authors report that under certain conditions it can increase the skin sensitivity of guinea pigs to 2,4-dinitrofluorobenzene (DNFB) ; Increases T-Lymphocyte Proliferation in Regional Lymph Nodes at Skin Sensitization The skin test was performed in Hartley miscellaneous guinea pigs that had been sensitized with DNFB and the DNFB solution was shaved at a concentration of 0.1%, 0.25%, 0.5% Of the guinea pig flank and recorded the skin reaction at 24, 48, 72 and 96 hours.The reaction intensity was divided into three grades: grade 3 skin redness, grade 2.5 skin red