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本文报道用高效液相色谱法测定消炎痛(lndomethacin)犬血浓度的方法和结果。应用本法测定了5只犬静脉给药消炎痛的血清浓度。计算其药代动力学参数平均值为:K=0.1757h~(-1) t1/2=4.28h。结果表明:消炎痛为=室模型药物,口服吸收完全。犬与人的体内代谢速率较一致。采用本法测定简便,快速,干扰少,灵敏度较高,取样量少,适合临床进行消炎痛血清浓度的监测。
This article reports the methods and results of determination of lndomethacin in dogs by high performance liquid chromatography. The serum concentration of indomethacin in 5 dogs was determined by this method. Calculate the pharmacokinetic parameters of the average: K = 0.1757h ~ (-1) t1 / 2 = 4.28h. The results showed that: indomethacin = room model drug, oral absorption completely. Dogs and people’s body metabolism rate more consistent. This method is simple, rapid, less interference, high sensitivity, less sampling, suitable for clinical monitoring of serum concentrations of indomethacin.