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目的探讨妊娠不同阶段阴道乳酸杆菌的分布特点。方法选择120例健康妊娠妇女,取其阴道分泌物行乳酸杆菌菌种鉴定,并对乳酸杆菌产生过氧化氢的情况进行检测。比较不同妊娠期阴道乳酸杆菌菌种的分布及不同乳酸杆菌产生过氧化氢的能力。结果 86.7%的妊娠期妇女阴道内能检测出乳酸杆菌。嗜酸乳酸杆菌为优势菌(76.9%),其次为德氏乳酸杆菌亚种(15.4%),卷曲乳酸杆菌最少(7.7%)。妊娠期阴道内能产生过氧化氢的乳酸杆菌的优势菌种为嗜酸乳酸杆菌。结论妊娠期阴道内能产生过氧化氢的乳酸杆菌的优势菌种为嗜酸乳酸杆菌,在维持妊娠期妇女阴道微生态平衡、防御阴道感染中起着重要作用。
Objective To investigate the distribution of vaginal lactobacilli in different stages of pregnancy. Methods A total of 120 healthy pregnant women were selected and their vaginal secretions were identified by Lactobacillus species, and the hydrogen peroxide production by Lactobacillus was detected. The distribution of different vaginal lactobacilli during gestation and the ability of different lactobacilli to produce hydrogen peroxide were compared. Results 86.7% of pregnant women were able to detect Lactobacillus in their vagina. Lactobacillus acidophilus was the dominant bacterium (76.9%), followed by Lactobacillus delbrueckii subsp. (15.4%) and Lactobacillus curvatus at least (7.7%). The dominant species of Lactobacillus that produces hydrogen peroxide in the vagina during pregnancy is Lactobacillus acidophilus. Conclusion The dominant species of Lactobacillus producing hydrogen peroxide during pregnancy is Lactobacillus acidophilus, which plays an important role in maintaining vaginal microecology balance and preventing vaginal infection in pregnant women.