胃肠道间质瘤(GIST)是胃肠道最常见的间叶组织源性肿瘤,约80%~90%胃肠道间质瘤发病机制为c-kit基因突变,导致KIT蛋白异常活化,引起肿瘤细胞不受控制的增殖。5%~10%的患者发病机制与血小板衍生生长因子α(PDGFRα)基因突变有关,5%的患者没有发现基因突变(野生型胃肠道间质瘤)[1] Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors in the gastrointestinal tract. About 80% to 90% of gastrointestinal stromal tumors are caused by mutations in the c-kit gene, leading to abnormal activation of KIT protein. Cause uncontrolled proliferation of tumor cells. In 5% to 10% of patients, the pathogenesis is related to the mutation of platelet-derived growth factor alpha (PDGFRα) gene, and 5% of patients have no gene mutation (wild-type gastrointestinal stromal tumor)