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目的通过定量方法研究测定习惯性流产(RSA)患者血清中的肿瘤坏死因子-α(TNF-α)及可溶性人白细胞抗原G(sHLA-G)的水平,探讨TNF-α及sHLA-G与习惯性流产有无相关性。方法选择早期妊娠孕妇100例,正常对照组:无自然流产史早期妊娠健康孕妇42例,RSA组:有习惯性流产史二次及二次以上的早期妊娠妇女58例,采用酶联免疫(ELISA)法定量检测两组样本血清中TNF-α及sHLA-G的水平。结果 RSA组血清中外周血淋巴细胞的TNF-α表达水平则明显高于正常妊娠组差异有显著性(P<0.05),而sHLA-G的表达水平明显低于正常对照组,差异有显著性(P<0.05)。结论妊娠早期孕妇血清中TNF-α及sHLA-G与妊娠成功有直接关系,TNF-α升高及sHLA-G降低可能会导致习惯性流产的发生。
Objective To quantitatively study the levels of serum tumor necrosis factor-α (TNF-α) and soluble human leukocyte antigen G (sHLA-G) in patients with habitual abortion (RSA) and to investigate the relationship between TNF-α, sHLA- Whether there is a correlation of abortion. Methods: A total of 100 pregnant women of early pregnancy were enrolled in this study. There were 42 healthy pregnant women with early pregnancy without spontaneous abortion. RSA group: 58 pregnant women with second and second trimester habitual abortion. Enzyme-linked immunosorbent assay (ELISA) ) Method was used to measure the levels of TNF-αand sHLA-G in serum of two groups. Results The level of TNF-α in peripheral blood lymphocytes of RSA group was significantly higher than that of normal pregnancy group (P <0.05), while the expression of sHLA-G was significantly lower than that of normal control group (P <0.05). Conclusion Serum TNF-α and sHLA-G in early pregnancy are directly related to the success of pregnancy. Increased TNF-α and sHLA-G may lead to habitual abortion.