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从链霉素中分离出的两类致敏性杂质“高杂1”、“高杂2”; 纯链霉素硫酸盐;两种链霉素蛋白结合物SM-BSA、SM-TT免疫家兔都可使家兔产生免疫应答。5种链霉素抗原按其在家兔中免疫应答的特点可分为二类:蛋白类抗原和非蛋白类抗原.蛋白类抗原的免疫原性较非蛋白类抗原的免疫原性强,且产生的链霉素抗体抗原结合部位的特异性主要为K_(SM)/K_B<1类型;非蛋白类抗原产生的链霉素抗体抗原结合部位的特异性主要为K_(SM)/K_B>1类型。 “高杂 1”和抗原结合部位特异性不同的链霉素血清的匹配程度,对其引发的豚鼠PCA反应影响较大。且“高杂1”引发链霉素速发型过敏反应的能力在豚鼠主动全身过敏反应模型中被进一步确证。
Two kinds of allergenic impurities isolated from streptomycin, “High impurity 1”, “High impurity 2”; streptomycin sulfate; two streptomycin protein conjugates SM-BSA, SM-TT immune home Rabbits can make rabbits immune response. The five streptomycin antigens can be divided into two categories according to their immune response characteristics in rabbits: protein antigens and non-protein antigens. The immunogenicity of protein antigens is stronger than non-protein antigens and The specificity of streptomycin antibody antigen-binding site was mainly K_ (SM) / K_B <1. The specificity of streptavidin antigen-binding site by non-protein antigen was mainly K_ (SM) / K_B> 1 Types of. The degree of matching of “high heterozygous 1” and streptomycin sera with different antigen-binding site specificity has a great impact on the PCA response induced by guinea pigs. Furthermore, the ability of “hyper-heterozygote 1” to trigger immediate hypersensitivity of streptomycin was further confirmed in the model of active systemic anaphylaxis in guinea pigs.