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六十年代后期了解到在HLA A、B、C抗原相同细胞之间作混合淋巴细胞培养(MLC)时所表现的异常增殖,是由于HLA-D区不同所致.后来证明HLA-D区产物可以用血清学方法检出,而且了解到在用抗体(Ia)和用T淋巴细胞(LD)识别的D区产物决定簇之间可能不同.现在,HLA A、B、C抗原称Ⅰ类MHC产物,而D抗原为Ⅱ类产物.现在我们对D区的了解,不仅是以血清学和T淋巴细胞对Ⅱ类产物的应答为基础,同时也是基于蛋白质和DNA的研
In the late 1960’s, it was learned that the abnormal proliferation exhibited by mixed lymphocyte culture (MLC) between the same cells of HLA A, B and C antigens was due to the difference in HLA-D regions, and later it was confirmed that the HLA-D region products could Is detected by serological methods and it is understood that there may be a difference between the antibody (Ia) and the D-region product determinant recognized by T lymphocytes (LD). Now HLA A, B and C antigens are referred to as class I MHC products , While the D antigen is a Class II product and now our knowledge of D is based not only on serological and T lymphocyte responses to class II products but also on proteins and DNA