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目的观察妊娠期糖尿病患者血清胰高血糖素样肽(GLP)-1水平并探讨其临床意义。方法对2014年8月至2015年2月产科门诊进行常规产检的孕中期妇女,进行75 g口服葡萄糖耐量试验(OGTT)试验,以区分妊娠期糖尿病(GDM)患者和妊娠期糖耐量正常(GNGT)者,再从两类孕妇中随机抽取各30例纳入GDM组、GNGT组作为研究对象。检测OGTT各时点(0、1、2 h)血清葡萄糖、胰岛素及GLP-1水平。结果 1h GLP-1水平在GDM组明显低于GNGT组[(11.15±4.84)pmol/L vs(13.96±6.58)pmol/L,P<0.05];1h GLP-1分泌指数GDM组亦低于GNGT组(0.53±0.42 vs 2.78±4.46,P<0.01),差异均有统计学意义。妊娠期GLP-1水平与体重(β=-0.475,P<0.01)及胰岛素抵抗指数(β=-0.258,P<0.05)呈负相关。结论 GDM患者GLP-1水平下降,餐后反应性下降更为明显,GLP-1可能参与了GDM的发生。
Objective To observe the serum level of glucagon like peptide (GLP) -1 in patients with gestational diabetes mellitus and to explore its clinical significance. METHODS: Pregnant women of the second trimester who underwent routine birth control from August 2014 to February 2015 were tested for oral glucose tolerance (OGTT) 75 g to distinguish gestational diabetes mellitus (GDM) and normal gestational glucose tolerance (GNGT ), And then from the two types of pregnant women randomly selected 30 cases were included in the GDM group, GNGT group as the study. Serum glucose, insulin and GLP-1 levels were measured at each time point (0, 1, 2 h) of OGTT. Results The GLP-1 level in GDM group was significantly lower than that in GNGT group [(11.15 ± 4.84) pmol / L vs (13.96 ± 6.58) pmol / L, P <0.05] Group (0.53 ± 0.42 vs 2.78 ± 4.46, P <0.01), the differences were statistically significant. The level of GLP-1 in pregnancy was negatively correlated with body weight (β = -0.475, P <0.01) and insulin resistance index (β = -0.258, P <0.05). Conclusion The GLP-1 level decreased and the postprandial reactivity decreased more obviously in GDM patients. GLP-1 may be involved in the occurrence of GDM.