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目的:分析联合应用间苯三酚与地屈孕酮治疗先兆流产患者的疗效。方法:将符合条件的先兆流产患者随机分成观察组与对照组各60例,观察组联合应用间苯三酚和地屈孕酮治疗,对照组仅用地屈孕酮治疗。对观察组与对照组的临床症状缓解及消失时间、继续妊娠率以及药物不良反应进行比较,出院后对患者进行随访,比较两组妊娠及分娩期并发症以及新生儿的不良结局。结果:观察组的继续妊娠率显著高于对照组。对照组临床症状缓解时间及消失时间均明显低于对照组。观察组出现胃肠道不适的患者明显少于对照组,差异均有统计学意义(P<0.05)。观察组和对照组妊娠及分娩期并发症和新生儿不良结局的差异不明显,差异无统计学意义。结论:联合应用间苯三酚与地屈孕酮治疗先兆流产疗效高于单纯使用地屈孕酮,药物不良反应少,建议临床推广。
Objective: To analyze the efficacy of combination of phloroglucinol and dydrogesterone in the treatment of threatened abortion. Methods: The eligible patients with threatened abortion were randomly divided into observation group and control group, with 60 cases in each group. The observation group was treated with phloroglucinol and dydrogesterone. The control group was treated with dydrogesterone only. The clinical symptoms of the observation group and the control group were relieved and disappeared, the rate of continuing pregnancy and adverse drug reactions were compared. After discharge, the patients were followed up. Complications of pregnancy and childbirth as well as the adverse outcomes of newborns were compared. Results: The continued pregnancy rate in the observation group was significantly higher than that in the control group. Control group clinical symptoms and disappearance of the time were significantly lower than the control group. The patients in the observation group with gastrointestinal discomfort were significantly less than those in the control group, the differences were statistically significant (P <0.05). There were no significant differences between the observation group and the control group in complications of pregnancy and childbirth and neonatal adverse outcomes, with no significant difference. Conclusion: The combined application of phloroglucinol and dydrogesterone in the treatment of threatened abortion is more effective than the simple use of dydrogesterone. There are few adverse drug reactions and the clinical recommendation is recommended.