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【目的】了解早产儿和足月儿败血症的临床特点,为早期诊断及临床指导用药提供依据。【方法】对2009年1月-2011年5月杭州市第一人民医院新生儿科病房血培养确诊为败血症的早产儿和足月儿的临床资料及药物敏感情况进行回顾性分析。【结果】早产儿胎膜早破发生率及使用静脉营养比例更高。早产儿败血症患儿更易于合并高胆红素血症、呼吸窘迫综合征、喂养不耐受、新生儿窒息;而足月儿败血症患儿发生脐炎的比例高于早产儿败血症患儿。G+菌是新生儿败血症的主要病原菌,足月儿G+菌发病率更高,而早产儿合并白色念珠菌的发病率更高。【结论】早产儿败血症患儿进行的有创操作更多,并发症更复杂,更易并发真菌感染。
【Objective】 To understand the clinical features of premature infants and full-term infantile sepsis and provide evidence for early diagnosis and clinical guidance. 【Methods】 The clinical data and drug susceptibility of premature children and term children diagnosed as sepsis in the blood culture of First People’s Hospital of Hangzhou from January 2009 to May 2011 were retrospectively analyzed. 【Results】 The incidence of premature rupture of membranes and the use of intravenous nutrition were higher. Premature infants with sepsis are more likely to be associated with hyperbilirubinemia, respiratory distress syndrome, feeding intolerance, and neonatal asphyxia; whereas those with full-term infantile sepsis have a higher prevalence of omphalitis than premature infants with sepsis. G + bacteria is the main pathogen of neonatal sepsis, term infants with higher prevalence of G + bacteria, while the incidence of Candida albicans preterm children with a higher incidence. 【Conclusion】 Infants with premature infants with septicemia have more invasive procedures, more complicated complications and more complicated fungal infection.