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为探讨尿NAG在肾脏疾病中的临床意义,采用固定时间法测定尿NAG。结果显示,尿Tp正常组患者尿NAG增高者占60％,尿Tp异常组患者尿Tp与尿NAG值较对照组增高(P<0.01),且尿Tp与NAG呈高度正相关(r=086,P<0.01)。当Ccr<70ml/min时尿NAG显著高于对照组(P<0.01),且随着Ccr的下降,尿NAG显著升高(P<0.01)。当药物透析等手段治疗有效时尿NAG显著降低(P<0.01),无效者则无变化(P>0.05)。提示尿NAG是诊断肾脏损害的早期、灵敏的指标,并可估计病情,观察疗效。
In order to explore the clinical significance of urinary NAG in renal disease, urine NAG was measured by fixed time method. The results showed that urinary NAG increased in 60% of patients with normal urinary Tp, and urinary Tp and urinary NAG in patients with abnormal urinary Tp increased (P <0.01), and urinary Tp was positively correlated with NAG (r = 086 , P <0.01). Urinary NAG was significantly higher when Ccr <70ml / min (P <0.01), and urine NAG was significantly increased with the decrease of Ccr (P <0.01). Urinary NAG was significantly decreased (P <0.01), but ineffective (P> 0.05) when drug treatment was effective. Urine is an early diagnosis of renal damage, sensitive indicators, and can estimate the condition, observe the effect.