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目的 :观察硫酸吗啡控释片治疗晚期癌痛的止痛疗效 ;方法 :本次观察共收治40例中、重度癌痛患者 ,硫酸吗啡控释片 30mg/ 1 2小时一次 ,常规起始剂量每天 60mg,在用药过程中根据疼痛缓解程度调整剂量由 60mg～ 1 2 0mg～ 1 80mg递增 ;结果 :镇痛显效 2 5例(62 .5 % ) ,有效 1 2例 (30 % ) ,无效 3例 (7.5 % ) ,总有效率为 92 .5 % ;药物最小剂量为 60mg ,最大日剂量为 2 70mg ,副作用只须对症处理 ,大部分患者均可耐受 ,未见有药物依赖性出现 ;结论 :硫酸吗啡控释片对中、重度癌痛镇痛效果好 ,服用方便 ,作为癌痛的第三阶段镇痛药为首选药物。
Objective: To observe the analgesic efficacy of morphine sulfate controlled-release tablets in the treatment of advanced cancer pain.Methods: Forty patients with moderate to severe cancer pain were treated in this study. Morphine sulfate controlled-release tablets (30mg / 1 2) once daily, conventional starting dose of 60mg , In the course of medication according to the degree of pain relief to adjust the dose from 60mg ~ 120mg ~ 180mg increments; Results: analgesic significantly effective 25 cases (62.5%), 12 cases (30%), 3 cases of ineffective 7.5%), the total effective rate was 92.5%; the minimum dose of drug was 60mg, the maximum daily dose was 2 70mg. The side effects were symptomatic treatment only, most of the patients were tolerant and no drug dependence was found.Conclusion: Morphine sulfate controlled-release tablets on the moderate and severe pain relief analgesic effect, easy to take, as the third phase of cancer pain analgesics as the drug of choice.