【摘 要】
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A sensitive analytical method to identify active metabolites of bitespiramycin in rat urine and bile was developed by liquid chromatography-electrospray ionizat
【机 构】
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Laboratory of Drug Metabolism and Pharmacokinetics
论文部分内容阅读
A sensitive analytical method to identify active metabolites of bitespiramycin in rat urine and bile was developed by liquid chromatography-electrospray ionization tandem mass spectrometry(LC/ESI-MSn).Bitespiramycin and its major active metabolites in rat urine and bile were isolated and identified as M1 serial(spiramycin I,II,III),M2 serial(platenomycin A1,josamycin and leucomycin A1)and M3 serial(deisovalerylplatenomycin A1,deisovaleryl-josamycin,deisovalerylleucomycin A1).
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