三苯氧胺作为绝经前雌激素受体阳性的乳腺癌患者的首选药物,可有效降低乳腺癌的复发率和转移率[1],但因需长期服用可导致包括脂肪肝在内的诸多不良反应。Nishino等[2]报道,乳腺癌患者服用三苯氧胺后两年内脂肪肝的发生率为43.2%。Kotiloglu等[3]报道,长期服用三苯氧胺可导致重度脂肪肝、肝纤维化、肝硬化,影响患者 Tamoxifen, as the drug of choice for premenopausal women with estrogen receptor-positive breast cancer, can effectively reduce the recurrence rate and metastatic rate of breast cancer [1]. However, long-term use can lead to many adverse reactions including fatty liver. Nishino et al [2] reported that breast cancer patients taking tamoxifen within two years after the incidence of fatty liver was 43.2%. Kotiloglu et al [3] reported that long-term use of tamoxifen can lead to severe fatty liver, liver fibrosis, cirrhosis, affecting patients