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1、试验了归芪胃友胶囊体外抗幽门螺旋杆菌活性,结果发现在浓度范围5.0~500g/L内具有剂量依赖性;和同浓度的三九胃泰胶囊相比,抑菌效果显著增强。2、通过用归芪胃友胶囊纠正小鼠模型脾虚验证其治疗慢性胃炎的药理作用,筛选了定量指标:肠比重、肠排钡速率和血清淀粉酶活性,分别反映:“脾虚”动物肠胀气、肠蠕动和自身代谢水平等。结果表明,归芪胃友胶囊治疗小鼠大黄灌胃引起的脾虚优于三九胃泰胶囊和传统补脾养胃方“四君子汤”。3、报道了归芪胃友胶囊急性毒性和慢性毒性试验结果。
1. The activity of Guiqi Weiyou capsule against Helicobacter pylori was tested in vitro and found to be dose-dependent in the concentration range of 5.0-500 g/L. Compared with Sanjiuweitai Capsule with the same concentration, the antibacterial effect was significant. Enhanced. 2. To verify the pharmacological effects of treatment of chronic gastritis by Guiqiweiyou capsule correcting the spleen deficiency of the mouse model, we screened the quantitative indicators: the proportion of intestine, the rate of intestinal discharge and the activity of serum amylase, respectively, reflecting: “Spleen deficiency” animal flatulence , peristalsis and their own metabolic levels. The results showed that Guiqiweiyou capsule treatment of spleen deficiency caused by intragastric administration of rhubarb was superior to Sanjiuweitai Capsule and traditional “Sijigazi Decoction”. 3. The results of acute toxicity and chronic toxicity test of Guiqi Weiyou Capsule were reported.