【摘 要】
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Dear Editor,rnIn the 1940s,Charles Huggins discovered that surgical castration produced remarkable palliative benefits for men with advanced prostate cancer,an effect we now understand to be mediated through depriving the androgen receptor (AR) from its l
【机 构】
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Division of Oncology, Department of Medicine, University of Washington, Seattle,WA 98116, USA;Clinic
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Dear Editor,rnIn the 1940s,Charles Huggins discovered that surgical castration produced remarkable palliative benefits for men with advanced prostate cancer,an effect we now understand to be mediated through depriving the androgen receptor (AR) from its ligands (i.e.,testicular-derived androgens).In the years since,medical forms of androgen deprivation therapy (ADT) have largely replaced orchiectomy as the predominate means of achieving castrate testosterone (T) levels,and currently,luteinizing hormone-releasing hormone (LHRH) agonists (e.g.,leuprolide) are the most common form of ADT.Importantly,studies have shown that LHRH agonists are clinically efficacious and,similar to surgical castration,drive T below 50 ng d1-1 for most patients.1
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