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研究表明FVC-P(益友病毒复合体中红血球增多症诱导株)感染的DBA/2小鼠,脾脏含白血病细胞和C型病毒颗粒,NK活性及骨髓细胞对PHA和ConA(刀豆球蛋白)的反应性下降,感染,后40天内死亡.但如果在感染后5和12天用150cGyTBI(全身照射)治疗,小鼠可生存370天以上,认为与细胞免疫的恢复有关.为进一步探讨其可能的机制,本研究在下列四组DBA/2小鼠中检测了IFN-γ、IL-2(白细胞介素-2)和BFU-E(红系祖细胞)特性;(1)正常小鼠;(2)TBI处理的正常小鼠;(3)FVC-P感染小鼠;(4)FVC-P感染后TBI处理小鼠.
It has been shown that DBA / 2 mice infected with FVC-P (induced by erythrocytisenzygium in Myvatow complex) contain leukemia cells and type C virus particles in the spleen, NK activity and effect of bone marrow cells on PHA and ConA (Concanavalin) , But died within 40 days after infection.However, if treated with 150 cGy TBI (total body irradiation) 5 and 12 days after infection, the mice survived more than 370 days and were considered to be related to the recovery of cellular immunity.To further explore its possible In this study, the characteristics of IFN-γ, IL-2 (interleukin-2) and BFU-E (erythroid progenitor cells) were detected in the following four groups of DBA / 2 mice: (1) normal mice; (2) normal mice treated with TBI; (3) mice infected with FVC-P; (4) mice treated with TBI after FVC-P infection.