Objective:To evaluate the effect of Chinese herbal medicine formula,modified Liujunzi Decoction(六君子汤,MLJZT),for anorexia,utilized as adjunct therapy during chemotherapy treatment for patients with advanced non-small cell lung cancer (NSCLC).Methods:The study adopted a propensity score-matched design based on a prospective database.From February 2016 to September 2017,patients with advanced NSCLC that received both cisplatin-besed chemotherapy and MLJZTr (IM group) were 1:1 propensity score-matched to patients that received the cisplatin-based chemotherapy alone (control group).Changes in anorexia and weight,as well as side effects were evaluated per week within 4-cycle chemotherapy.Results:Overall,156 patients with advanced NSCLC that had received chemotherapy from our database were identified and 53 pairs were matched successfully.In total,48.6％ (50/53) of patients in the IM group had anorexia-improvement compared to 28.3％ (15/53) of patients in the control group,and a total of 39.6％ (21/53) of patients in the control group had a worsening of anorexia compared to only 7.8％ (5/53) of patients in the IM group (P＜0.01).The weight reduced significantly over time in the control group (-2.36_+2.53 kg) as compared to the IM group (-0.62±3.89 kg,P＜0.01).CHM didn\'t reduce the efficacy of chemotherapy in shrinling tumor size,and didn\'t increase the incidence of side effects such as hematological and hepatorenal toxicity.Conclusion:MLJZT is effective and safe for alleviating anorexia in patients with NSCLC.These findings warrant the conduct of a randomized controlled trial.