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心肌成纤维细胞在心脏中是数量最大的细胞,它们通过维持细胞外基质平衡在受损或衰竭心脏中纤维化心肌重塑发挥重要作用。它既调节正常的心脏功能,也参与高血压病、心肌梗死和心力衰竭等的不良心肌重塑。综述心肌成纤维细胞的特性,包括起源、机械电特性、细胞外基质代谢中的作用,以及正常和病理状态下心肌成纤维细胞对环境刺激的功能反应和分泌生物活性因子的能力,并总结以心肌成纤维细胞为靶细胞调节心肌纤维化的研究现状。
Cardiac fibroblasts are the largest number of cells in the heart and they play an important role in maintaining fibroblastic remodeling in damaged or failed hearts by maintaining an extracellular matrix balance. It regulates normal heart function as well as defective myocardial remodeling such as hypertension, myocardial infarction and heart failure. The characteristics of cardiac fibroblasts, including their origin, mechanical and electrical properties, the role of extracellular matrix metabolism, and the ability of cardiac fibroblasts to respond to environmental stimuli and to secrete bioactive factors under normal and pathological conditions were summarized and summarized Myocardial fibroblasts target cells regulate myocardial fibrosis research status.