论文部分内容阅读
目的:探讨血脂与中青年人脑梗死的关系。方法:检测了111例中青年人脑梗死患者及80例对照者的三酰甘油、总胆固醇、高密度脂蛋白胆固醇(Highdensitylipoproteincholesterol,HDL-C)、低密度脂蛋白胆固醇(Lowdensitylipoproteincholesterol,LDL-C)、载脂蛋白A-I(apolipoproteinA-I,ApoA-I)、载脂蛋白B100(apolipoproteinB100,ApoB100)和脂蛋白(a)血清含量。结果:脑梗死组三酰甘油犤(1.92±1.33)mmol/L犦,总胆固醇犤(5.21±1.08)mmol/L犦,LDL-C犤(3.13±0.96)犦mmol/L,ApoB100犤(1.10±0.29)g/L犦及脂蛋白(a)犤(0.23±0.18)犦g/L水平高于对照组(t=2.523～3.796,P<0.05),总胆固醇与年龄呈正相关犤青年:(4.96±1.14)mmol/L,中年:(5.27±1.06)mmol/L犦,HDL-C与年龄呈负相关犤青年:(1.39±0.43)mmol/L,中年:(1.26±0.35)mmol/L犦。亚组分析发现青年人脑梗死亚组的脂蛋白(a)水平和中年人脑梗死亚组的三酰甘油、总胆固醇、LDL-C、ApoB100及脂蛋白(a)水平均显著高于相应的对照组(t=2.571～4.107,P<0.05);皮层支动脉闭塞亚组脂蛋白(a)水平显著高于穿通支动脉闭塞亚组(t=5.414,P<0.01);首发脑梗死亚组与复发脑梗死亚组之间的血脂水平无显著差异。结论:血脂代谢紊乱是中青年人脑梗死的危险因素。
Objective: To investigate the relationship between blood lipids and cerebral infarction in young adults. Methods: The levels of triglyceride, total cholesterol, high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) in 111 middle-aged and young patients with cerebral infarction and 80 controls were detected. , Apolipoprotein A-I (ApoA-I), apolipoprotein B100 (ApoB100) and lipoprotein (a) were detected by ELISA. Results: The levels of triglyceride (1.92 ± 1.33) mmol / L, total cholesterol (5.21 ± 1.08) mmol / L, LDL-C 犤 (3.13 ± 0.96) 犦 mmol / L, ApoB100 脑(0.23 ± 0.18) 犦 g / L was higher than that of the control group (t = 2.523 ~ 3.796, P <0.05), total cholesterol was positively correlated with age (1.39 ± 0.43) mmol / L, middle age (1.26 ± 1.14) mmol / L, middle age (5.27 ± 1.06) mmol / L and HDL-C / L 犦. Subgroup analysis found that the levels of lipoprotein (a) and triglyceride, total cholesterol, LDL-C, ApoB100 and lipoprotein (a) in the subgroup of middle cerebral infarction were significantly higher than those of the corresponding group (T = 2.571 ~ 4.107, P <0.05). The level of lipoprotein (a) in subcortical branch occlusion subgroup was significantly higher than that in perforating branch occlusion subgroup (t = 5.414, P <0.01) There was no significant difference in blood lipid levels between the subgroups and the recurrent cerebral infarction group. Conclusion: Dyslipidemia is a risk factor for cerebral infarction in middle-aged and young people.