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目的观察细辛水煎剂与硝苯地平伍用的镇痛作用。方法采用醋酸致小鼠扭体法。结果在研究不同剂量细辛对小鼠镇痛作用的实验中确定26.6mg/kg为阈下镇痛值。细辛26.6mg/kg和硝苯地平2.5mg/kg单用均无镇痛作用,而联用后有明显镇痛作用,扭体次数较蒸馏水组降低50%(P<0.01),与单用细辛组相比减少54%(P<0.01)。结论硝苯地平可增强细辛水煎剂的镇痛作用,二者合用不失为一种有效的中西药结合组方的镇痛药。
Objective To observe the analgesic effect of asarum decoction combined with nifedipine. Methods acetic acid induced writhing in mice. Results In the study of different doses of Asarum analgesic effect in mice experiments to determine the value of 26.6mg / kg subthreshold analgesia. Asarum 26.6mg / kg and nifedipine 2.5mg / kg alone were no analgesic effect, and combined with significant analgesic effect, the number of writhing 50% lower than the distilled water group (P <0.01), and single use Asarum compared to 54% reduction (P <0.01). Conclusion Nifedipine can enhance the analgesic effect of Asarum Decoction, and the combination of the two can be an effective analgesic for the combination of traditional Chinese and western medicine.